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Methylpenidate Hydrochloride

385.00

Quantity

Description

Methylphenidate hydrochloride, USP is a central nervous system (CNS) stimulant.

Methylphenidate hydrochloride extended-release capsules (LA) are an extended-release formulation of methylphenidate with a bi-modal release profile. Each bead-filled methylphenidate hydrochloride extended-release capsule (LA) contains half the dose as immediate-release beads and half as enteric- coated, delayed-release beads, thus providing an immediate release of methylphenidate and a second delayed release of methylphenidate. Methylphenidate hydrochloride extended-release 10, 20, 30, 40, and 60 mg capsules (LA) provide in a single dose the same amount of methylphenidate as dosages of 5, 10, 15, or 20, or 30 mg of methylphenidate hydrochloride tablets given twice a day.

The active substance in methylphenidate hydrochloride extended-release capsules (LA) is methyl α- phenyl-2-piperidineacetate hydrochloride, and its structural formula is

Chemical Structure

Methylphenidate hydrochloride, USP is a white, odorless, fine crystalline powder. Its solutions are acid to litmus. It is freely soluble in water and in methanol, soluble in alcohol, and slightly soluble in chloroform and in acetone. Its molecular weight is 269.77.

Inactive ingredients: sugar spheres (which contain sucrose and starch (corn)), hypromellose, cellulose acetate butyrate, hypromellose acetate succinate, acetyltributyl citrate, acetone, talc, and purified water. Opaque gelatin capsules contain: titanium dioxide and gelatin. The 10 mg capsule contains FD&C Green #3, FD&C Red #40, and FD&C Yellow #6. The 30 and 40 mg capsules contain D&C Red #28 and FD&C Blue #1. The 60 mg capsules contain iron oxide yellow and sodium lauryl sulfate. The capsules are imprinted with black ink which contains black iron oxide, shellac and potassium hydroxide. The 60 mg black imprinting ink also contains ammonium hydroxide and propylene glycol.

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